产品货号：
Z13774
中文名称：
CTBP1抗体
英文名称：
Anti-CTBP1 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-CTBP1 Antibody |
| 指标别名 | BARS;C terminal binding protein 1;CTBP;CTBP1 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,IHC |
| 基因名称 | CTBP1 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthetic peptide corresponding to a sequence at the C-terminus of human CtBP1(425-440aa QTVKPEADRDHASDQL),different from the related rat and mouse sequences by one amino acid. |
| 实际分子量 | 48KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | CTBP1,C-terminal-binding protein 1,is a protein that in humans is encoded by the CTBP1 gene.The CtBP1 protein binds to the C-terminus of adenovirus E1A proteins.This gene is mapped to 4p16.This phosphoprotein is a transcriptional repressor(corepressor) and may play a role during cellular proliferation.This protein and the product of a second closely related gene,CTBP2,can dimerize.CtBP1 and CtBP2 preferentially associate with the E1A via a 5 amino acid motif,PLDLS,to repress E1A induced oncogenesis and cellular transformation.CtBP1 is expressed from embryo to adult,but CtBP2 is mainly expressed during embryogenesis.During skeletal and T cell development,CtBP1 and CtBP2 associate with the PLDLSL domain of delta EF1,a cellular zinc finger-homeodomain protein,and thereby enhances delta EF1-induced transcriptional silencing.In addition,CtBP complexes with CtIP,a 125kDa protein that recognizes distinctly different protein motifs from CtBP.CtIP binds to the BRCT repeats within the breast cancer gene BRCA1 and enables CtBP to influence BRCA1 activity.Both proteins can also interact with a polycomb group protein complex which participates in regulation of gene expression during development.Alternative splicing of transcripts from this gene results in multiple transcript variants. |
| Uniprot ID | Q13363 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 基因名全称 | C-terminal binding protein 1 |
| 蛋白名全称 | C-terminal-binding protein 1(CtBP1) |
| 推荐稀释比 | Western blot(WB) 1:500～2000 Immunohistochemistry in paraffin section (IHC) 1:50～400 (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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